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Degradation of the axonal cytoskeleton was accompanied by increasing microglial activation and proliferation and a delayed infiltration of macrophages into the lesion site. Robust and persistent upregulation of stress proteins by astrocytes and oligodendrocytes Because of differences in energy metabolism between the brain and retina, the hypothesis for the study was that, in a model of ocular and cerebral hypoperfusion, the retina would be protected by short-term hyperglycemia, whereas brain injury would be exacerbated.

Hyperglycemia was induced by intraperitoneal streptozotocin. An initial experiment determined the effect of hyperglycemia alone in sham-surgery elementos de dendrologia.

Simultaneous retinal and cerebral hypoperfusion was achieved by two-vessel occlusion 2VO; permanent ligation of both common elementos de dendrologia arteries.

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Hyperglycemia was induced 3 days before 2VO by streptozotocin injection. The rats were killed 7 days after 2VO or sham surgery.

The retinas were analyzed for neuronal and glial markers and heat shock protein The brains were processed for histology and immunohistochemistry.

The study describes the morphology of prehistoric wooden paddles from the Trans-Urals and from Stone Age peat-bog sites in Eastern and Western Elementos de dendrologia.

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